Hyperuricemia means high blood uric acid. Uric acid is the relatively water-insoluble end product that comes from the breakdown of purines in your diet. If too much uric acid is made, or the body doesn't efficiently clear away uric acid from your body, then it can lead to heavy uric acid in the body. Three forms of kidney diseases have been attributed to excess uric acid: acute uric acid nephropathy, chronic urate nephropathy and uric acid nephrolithiasis.
Hyperuricemia may harm the kidney in three ways: by forming renal stones, by blocking tubules and causing acute renal failure, and in those with gout it may contribute to chronic interstitial nephritis.Back top
Hyperuricemia Nephropathy occurs due to excess accumulation of uric acid in bloodstream. Factors that cause persistent elevation of uric acid concentration mainly include the follows:
1. Increased production of uric acid
1) Genetic factors
2) Acquired factors, including eating too much purine, overweight, high blood triglyceride, too much dietary sugar intake, alcohol addiction, etc.
2. Reduced excretion of uric acid:
1) Genetic factors: uric acid excretion fraction is reduced obviously
2) Acquired factors: improper intake of medicines like Thiazide diuretics and salicylic acid salt; reduced blood volume; high blood pressure, etc.
3. Excessive production of endogenous uric acid
4. Uric acid excretion barrierBack top
Almost all patients experience increased urination in early disease course due to impaired renal tubular concentration function. If stones form in the kidneys or ureters, some of the problems may include:
●Blood in the urine.
●Uncomfortable or painful urination.
Some patients accompany microalbuminuria, with 24-hour urine protein no more than 1.5g. Microscopic blood in urine and slight white blood cells are sometimes seen.
Combined high blood pressure, hyperlipedemia and metabolic syndrome also sometimes occur, which increases risks of renal arterial sclerosis and cardiovascular diseases.
In case of Acute Hyperuricemia Nephropathy, blood uric acid elevates sharply in a short time due to dissolving of excess cells and nucleic acid. The high uric acid can cause urinary tract obstruction and lead to sudden kidney failure. When this happens, symptoms can include:
●Nausea and vomiting.
●Lethargy and seizures.
●Complete kidney failure with the inability to pass your water or urinating less.Back top
Hypericemia Nephropathy results from high uric acid in the bloodstream. Uric, creatinine and blood urea nitrogen are metabolic wasteful products. If kidneys are working properly, those harmful toxins can be removed by the kidneys. High uric acid means that the kidneys filtering function has been impaired. Elevated blood uric acid can result in gout, which is also known as hyperuricemia. Advanced kidney disease or kidney failure may occur if not treated appropriately. Generally, treatments for Hyperuricemia Nephropathy mainly include the following aspects:
Basic treatment: dietary restriction is important. Avoid rich purine content foods, such as animal viscera, bone morrow, seafoods, etc. Vegetables, milk and eggs which don' t contain purine allowed. Avoid over fatigue. Restrict alcohol or cigarettes. Restrict medicines that may restrict excretion of uric acids such as hydrogen chloride thiazide diuretics.
Medicine treatment: medicines that inhibit synthesis or reabsorption of uric acids are often combined to reduce high levels of blood uric acids.
Micro-Chinese Medicine Osmotherapy:
Analyzed from pathology, Hyperuricemia Nephropathy is renal tubular epithelial cell disease. Excessive urates which are separated out due to high levels of uric acids activate inflammation response on renal tubular epithelial cells, further causing phenotype transdifferentiation of renal tubules. Normal physiological functions of renal tubules are impaired as a consequence. As initial inflammation stage, there can be no obvious symptoms. However, as fibrosis and scarring to renal tubular cells are deteriorating, symptoms such as hematuria, proteinuria, low urine specific gravity and other conditions may present.
Micro-Chinese Medicine Osmotherapy treats Hyperuricemia Nephropathy through the following processes:
Dilate blood vessels. As long as urate crystals deposit on kidneys, renal tubular epithelial cell ischemia and hypoxia will occur. The purpose of expanding blood vessels is to improve renal blood circulation and relive renal ischemia and hypoxia, which will provide a favorable environment for repairing of renal tubular epithelial cells.
Anti-inflammation. Reduce infiltration of inflammatory factors and control further damage to renal tubular epithelial cells.
Anti-coagulation. Gathered inflammatory cells in bloodstream will increase blood stasis and promote formation of renal capillary thrombosis. Anti-coagulation medicines can reduce blood thrombosis thus laying foundation for repairing of renal epithelial cells.
Degeneration. Deposited urate crystals will cause increasing inflammatory cells, micro-thrombosis and excellular matrixes on renal tubular capillaries. Thereby, it is essential to degenerate those deposits and ECM by using relevant medicines.Back top
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