What Pathological Conditions Exhibit Hyperuricemia

Hyperuricemia is the medical name of high blood uric acid, a final product of purine metabolism in human beings. The high levels of uric acids can cause a variety of problems, including acute Obstructive Nephropathy, urinary tract stones, arthritis, etc. The occurrence of Hyperuricemia is associated to metabolic disorders, and the pathological conditions that exhibit Hyperuricemia is actually a complicated process. The following will give a brief introduction on this.

Unlike allantion, the more soluble end product found in lower animals, uric acid is a poorly soluble end product of purine metabolism in humans. In human beings, approximately two thirds of urate is produced endogenously, and the remaining one third is from dietary purines.

If people eat much foods that contain rich purines, such as meat, beans, plant buds, seafoods, etc, this can cause blood uric acid levels to increase. If blood uric acid levels exceed its saturation, those substances can finally become crystalline and deposit in soft tissues. For people who suffer from hyperuricemia for long-term, the urate crystallines may lead to Obstructive urinary tract diseases.

The common cause of persistent Hyperuricemia is decreasing renal filtration function, which typically occurs in patients who receive long-term diuretic treatment and various types of primary kidney disorders. In human body, the production of uric acid is a complicated process which requires the participation of some enzymes. Those enzymes include two types: one type for promoting the synthesis of uric acid, and the other type for inhibiting formation of uric acids. Human beings have higher levels of uric acid, in part because of a deficiency of the hepatic enzyme, uricase, and a lower fractional excretion of uric acid.

The above introduces the pathological conditions that exhibit Hyperuricemia. Clinically, Hyperuricemia can be primary secondary to another medical condition. The occurrence of Hyperuricemia is often associated to obesity, high blood pressure, arterial sclerosis, coronary disease, lipid metabolic disorders, etc. Secondary causes of Hyperuricemia include certain medicines or some systemic diseases. The treatment for Hyperuricemia focuses on controlling the primary leading cause, restricting the intake of purine and treating the problems caused by the disease.