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How is Henoch-Schonlein Purpura(HSP) Nephritis Diagnosed

2012-09-18 17:28

A clear diagnosis is of course essential in treatment of any disease. Without right diagnosis, a lot of time may be wasted and the patients can not get satisfactory treatment effects. If you are suspected as Purpura Nephritis or showing signs of this disease, then you may want the answer: Why is it this disease? how is my kidney condition going on? What is the right treatment? From the following set of lab values, a lot of information will be obtained not only on the diagnosis but also extent of renal damage.

Clinical diangosis for HSP mainly includes the following tests:

 ☆ Test for specific inducing allergens

Allergens that may have induced Henoch-Schonlein Purpura Nephritis can be categorized into two types, inhalant allergens and food allergens. Testing out the spesific substance causing the disease is important for further prevention. Commonly tested items include willow, poplar, elm, shrimp, beef, mutton, crab, milk, peanuts, dust mites, etc.

 ☆Immunoglobulin testing

Immunoglobulin testing will help to judge humoral immune status. IgA dominated immune complex deposition on kidneys played key role in occurrence of Purpura Nephritis. The disease will cause high levels of immunoglobulin IgA bloodstream.

 ☆Complement testing

The testing will indicate the extent of activation of the complement system. Five complements will be tested, that is, C3, C4, CH50, C1q and B factor. Reduced results of complements indicate immune system dysfunction in eliminating immune complexes.

 ☆Lymphocyte subset test

Lymphocyte subset test will help for evaluating immune function of organism. Normally, T lymphocytes played key role in eliminating antigens and mediating inflammatory response. B lymphocytes will produce specific antibodies to mediate humoral immunity. Lowered levels of Treg cells, Th1 and Th2 will cause insufficiency of immunosuppressive factors thus inducing abnormal immune response.

 ☆Testing for blood in urine

Most patients with Purpura Nephritis experience hematuria resulting from loss of red blood cells. The doctors will do a further test to confirm the cause of blood in urine-----whether the damage causing this symptom is in renal glomerulis or renal tubules, or combination of the two. Right diagnosis will provide guidance for further treatment to stop the symptom and control the disease.

 ☆Other important tests:

Urine IgG testing will indicate whether glomerular filters have been damaged and sensitivity to drugs;

Urine a1-microglobulin testing will confirm whether renal tubular reabsorption has been impaired and degree of damages;

Urine GGT and GGT tests are criteria for juding renal tubular inflammatory injury and damage degree;

Urine osmotic pressure test will confirm distal renal tubular reabsorption function injury.

The above is a general introduction on how is Henoch-Schonlein Purpura Nephritis Diagnosed. For more about it , you may contact us or leave us a message.

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