Steroid-Resistant Nephrotic Syndrome with Protein in Urine

Steroid-resistant nephrotic syndrome refers to that the patients have no urinary remission following 4 weeks of prednisone 60mg/m2/day.Protein in urine is a typical sign of the disease.If the patients do not respond to steroid, what else treatment should they have?

Steroid-resistant nephrotic syndrome with protein in urine

Steroid is the first-line treatment option for Nephrotic Syndrome.It can decrease the permeability of renal blood vessels to lower the leakage of protein from body.If the patients respond to steroid,they will have a remission after a period of treatment.A typical signal of remission of nephrotic syndrome is relief of protein in urine.

However,if the patients do not have a response to steroid,it can cause renal function to decline rapidly.Therefore,it is important for the patients with steroid-resistant nephrotic syndrome to seek for an alternative treatment.

Treatment for steroid-resistant nephrotic syndrome with protein in urine

Immunotherapy is an alternative treatment for steroid-resistant nephrotic syndrome.It works in the following ways to treat the disease.

-Suppress the inflammatory response in kidneys

Immunotherapy can suppress the inflammatory response in kidneys.When the immune damage is inhibited,renal function will stop deteriorating.

-Correct immune dysfunction and rebuild normal immune system

Abnormal immune system is the underlying cause of nephrotic syndrome.Immunotherapy can correct immune dysfunction and help the body rebuild normal immune system.If so,the immune system will return to protect the body instead of attacking kidney tissues.

-Restore the impaired glomeruli

Immunotherapy can activate the self-regeneration and self-healing of the impaired glomeruli.Once the glomeruli are restored,the kidney function will be improved remarkably.

If the patients with steroid-resistant nephrotic syndrome have a good response to immunotherapy,they will have a remarkable improvement. Protein in urine, swelling, edema and other clinical symptoms will be controlled. Creatinine and BUN levels will lower greatly.