What is Mesangial proliferative glomerulonephritis(MPGN)

Mesangial proliferative glomerulonephritis(MPGN) is a rare kidney disorder characterized by blood in the urine caused by a particular type of inflammation inside the kidneys. Symptoms of the disease mainly include blood in urine, protein in urine and generalized swelling. Proper treatment of the disease is important so as to stop the conditions from progressing into end-stage renal disease.

What causes Mesangial Proliferative Glomerulonephritis(MPGN)? The immune system abnormalities result in abnormal immune deposits in the mesangial cells (part of the capillaries inside the kidneys) of the kidneys. The mesangial cells become bigger and their numbers increase as a result. The glomerular cells are normally responsible for filtering bloodstream and stopping proteins and red blood cells from entering urine. With the disease, people typically experience proteinuria, hematuria and high blood pressure.

Treatment of Mesangial Proliferative Glomerulonephritis(MPGN) is dependant upon the cause of the disease, whether it is acute or chronic, the severity of renal impairment, as well as the age and comorbidities of the patient, but mainly includes prevention of infections, immunosuppressants to suppress the immune system and fish oil to treat progressive MPGN. However, the illness condition may progress even with the methods. Proper treatment for the disease should include repairing the injured renal cells and stopping further worsening of the illness condition.