The Pathology Related With Mesangial Proliferative Glomerulonephritis

Mesangial Proliferative Glomerulonephritis (MsPGN) is based on light microscope to diagnosis nephritis. It is a group of diffuse glomerular mesangial cell proliferation and mesangial matrix in different level as the main characteristics of glomerular disease. Well, what is the pathology related with mesangial proliferative glomerulonephritis?

The pathogenesis of mesangial proliferative glomerulonephritis:

The pathogenesis of mesangial proliferative glomerulonephritis is unclear and it generally can be divided into immune pathogenesis and non-immune pathogenesis.

Immune pathogenesis includes that immune reaction leads to immune complexes and complement acting on mesangial cells directly. Besides, inflammation reaction will cause lymphocyte activation and abnormal secretion of cytokines, which results in mesangial cells and cytokines acting on each other.

Non-immune factors like high blood pressure, hyperperfusion and platelet dysfunction can also cause mesangial pathological changes.

Immune complexes found in mesangial proliferative glomerulonephritis include IgG, IgM, IgA and complement C3. This indicates that immune complexes can cause diseases. In addition, when immune factors are eliminated, glomerulonephritis in some patients continues to develop, which indicates that non-immune factors have effect on mesangial proliferative glomerulonephritis. For example, hyperperfusion of glomerular and high blood pressure in glomerular can cause mesangial sclerosis.

The treatment for mesangial proliferative glomerulonephritis

Here we recommend you a latest treatment for mesangial proliferative glomerulonephritis. This therapy is Immunotherapy which aims at suppressing the abnormal activity of immune system to stop further immune damage to kidneys. It can also degrade immune complexes in kidneys caused by abnormal immune reaction. By improving blood circulation, the harmful substances will be brought out of body. It also helps correct immune dysfunction and enhance normal immunity so as to prevent the relapse of mesangial proliferative glomerulonephritis. More importantly, Immunotherapy can stimulate the self-healing ability of kidneys and repair the damaged glomeruli so as to improve renal function.