Causes And Management Of Proteinuria In Lupus Nephritis

Lupus Nephritis is a kind of kidney disease which is caused by systemic lupus erythematous. The common symptom of Lupus Nephritis is large amount of proteinuria. Why do people have proteinuria and how quickly can proteinuria be developed in Lupus Nephritis?

Why proteinuria occurs in Lupus Nephritis?

Lupus Nephritis is an autoimmune disease. Autoimmune disease refers that when there is something wrong with your immune system, you cannot fight against attacks from outside as usual. In addition, antibodies released by your immune system attacks healthy cells as well, which causes damage on your health. Many immune complexes are formed when antibodies and antigen are combined. They cannot be removed by the abnormal immune system.

In Lupus Nephritis, IgG, IgA, C3 and immune complexes deposit in blood vessels. When they stay in tiny blood vessels of kidneys, your body will form inflammation to remove them. During this course, the inflammation can impair the tiny blood vessels which help to filter blood and preserve protein in body in a normal range. Therefore, protein will leak through glomeruli and into urine. This is how proteinuria is formed.

How quickly can proteinuria be developed?

In early stage of Lupus Nephritis, proteinuria is not so obvious and severe. Patients have proteinuria which amounts to 1g/d. However, along with more and more cells damaged, much more protein will leak into urine. In severe cases, proteinuria is amount to 3.5g/d. That is the reason why proteinuria can be developed so quickly.

If you do not take effective measurements to treat it, proteinuria will aggravate your kidney function. For a long time, your kidney disease may advance into kidney failure. At this time, proteinuria will become less due to less survival kidney cells. In this case, many toxics will deposit in blood vessels, which will lead to many complications.

Knowing what causes your proteinuria and then you should try to treat it. You may control your proteinuria through the following methods:

1. You can take ACEI and ARBs after getting your doctors’ permission. These medicines may be helpful for you to treat proteinuria.

2. You can also use steroid and immunosuppressive agents which contribute to control inflammation in kidneys and are useful in controlling proteinuria. However, you should not use these medicines for a long time because they will bring some side-effects.

3. You should lower your high blood pressure. Along with high blood pressure, proteinuria also occur, and this is because high blood pressure will weaken capillaries in the kidneys.

The above tell why proteinuria occurs and how it progresses into large amount of massive proteinuria in Lupus Nephritis. Any unclear about proteinuria in Lupus Nephritis, you can leave us a message to kidneycares@hotmail.com or just consult our online consultants directly.