What Causes Lupus Nephritis?

Lupus Nephritis refers a medical condition that inflammation caused by SLE (Systemic Lupus Erythematosus) damages renal tissues. SLE is an autoimmune disease, which means there is a problem with the body's immune system. Lupus Nephritis is the complication of SLE, so the root cause of it is immunodeficiency as well.

Normally, the immune system helps protect the body from harmful substances, but in patients with an autoimmune disease, the immune system is too weak to fight against harmful substances, or it fails to tell difference between harmful substances and healthy one. Under such a condition, antigen like bacterium or virus attacks body easily. They invade body and form immune complexes with antibody which is produced by body to against them. Immune complexes should be eliminated with strong immune system; however, because of immunodeficiency, they exist in the body and circulate with blood. When immune complexes deposit in kidney and cause inflammation, Lupus Nephritis is caused.

Generally speaking, immune complexes may deposit in any part of our body like heart, skin and bone and so on, causing different problems. Lupus Nephritis is just one of the potential problem of immunodeficiency, so the key point to prevent Lupus Nephritis is not to treat kidney, but to normalize immune system as well as strengthen immunity.

Since immunodeficiency is the real cause of Lupus Nephritis, treatment for Lupus Nephritis should starts with immune system, not simply control symptoms. Lupus Nephritis symptom is just the manifestation of kidney damages, not the root causes. Without eliminating the root cause of Lupus Nephritis, more and more immune complexes will be produced and deposit in kidney, which can accelerate Lupus Nephritis progresses to kidney failure. Therefore, normalizing immune system is the only and best way to stop Lupus Nephritis radically.