Kidney Failure due to Diabetes: How Can There Be Some Protein in Urine

A:

Nowadays the morbidity of diabetes becomes higher and higher. Years of diabetes has many complications, one of which is kidney failure. Proteinuria is common symptom of kidney failure. And it is associated with a series of pathological change.

Glomerular hemodynamics abnormality

Glucose metabolic disorders can stimulate the activating factor to blood vessels so as to expand the glomerular afferent arteries. This can increase the blood flow to glomerular capillaries, raising glomerular filtration so that plasma albumin can be filtered out of the body.

Glomerular filtration membrane function disorder

Glomerular filtration membrane is classified into three aspects, namely, endothelial cells, basement membrane and sertoli cell. Diabetic Nephropathy changes the function of glomerular filtration membrane so that protein can not be preserved in body. It is the main cause of proteinuria.

Renal tubular acidosis

Under normal circumstance, the filtered protein can be reabsorbed by renal tubule and only few protein can be filtered out of the body. When blood sugar level is high, it inhibits the proliferation of renal tubule epithelial cells and triggers renal tubule epithelial cells to divide into myofibroblast so as to affect their reabsorb function. And then protein comes into the urine without being reabsorption.

VEGF abnormality

VEGF can regulate the production of blood vessels and permeability of endothelial cells. With diabetes, the secretion of VEGF increases, which increases protein leakage.

Proteinuria indicates that her kidneys are damaged and the patient needs timely and effective treatment to stop proteinuria and protect the remaining kidney function. Only in this way can she gets rid of dialysis. Conventional treatment, such as steroids, immunosuppressants. ACEI and ARBs can help you eliminate proteinuria, but it can not restore kidney function. TCM treatment can make up the shortcoming of conventional treatment and help you avoid dialysis. For more information about kidney failure due to diabetes, please contact online doctor.