Can IgA Nephropathy Be Cured

Can I be cured? This is a common question posted by IgA Nephropathy who are newly diagnosed. As for this question, I am so sad to say IgA Nephropathy can not be cured, but please do not be negative, as it can be remitted completely with Immunotherapy in some cases.

Why IgA Nephropathy can not be cured?

IgA Nephropathy is an autoimmune disease marked by deposition (mainly IgA immune complexes) in mesangial area. IgA immune complexes are formed when antigen combines with antibody. They circulate with blood and may deposit in any part of our body. When IgA immune complexes are formed and deposit in mesangial area, inflammation occurs. Inflammation helps to remove IgA immune complexes, and meanwhile they damage surrounding kidney tissues directly. When kidney tissues are damaged, they lose their working ability and become dead finally. Dead kidney tissues can not be revived, so IgA Nephropathy can not be cured.

How is IgA Nephropathy treated by Immunotherapy?

Immunotherapy treats IgA Nephropathy by several steps:

Steps 1: exact diagnosis. We must make sure the exact type and amount of deposition in kidney before the real treatment and this is essential for the following prescription.

Step 2: block inflammation. Inflammation damages surrounding kidney tissues, so it is the direct cause of kidney damages in IgA Nephropathy. For people with IgA Nephropathy, when inflammation is blocked, further kidney damages are avoided effectively.

Step 3: Immune tolerance. Deposition in kidney can not be removed over night, so we need patient’s kidney to coexist with deposition for some time.

Step 4: Clearance of deposition. Although deposition in kidney can not be removed over night, they can be cleared away little by little. For people with IgA Nephropathy, as long as deposition are removed, inflammation is prevented effectively and also no kidney damages are caused any more.

Step 5: Adjust immune system. IgA immune complex is the combination of antigen and IgA antibody. When disordered immune system is normalized, no antigen can invade successfully, and also no IgA immune complexes are formed.

Step 6: Immune protection. In Immunotherapy, this step focuses on protect patient’s immune system and healthy kidney tissues, and this will strengthen the prevention to kidney problem.

IgA Nephropathy can not be cured. And although it can be treated effectively with Immunotherapy. Not everyone with IgA Nephropathy will certainly get completely remission. To receive obvious treatment effects, IgA Nephropathy patients need to have a early diagnosis and timely treatment.