How to Reduce Blood In Urine with IgA Nephropathy

Blood in urine is a leading symptom of IgA Nephropathy. In some cases, it is visible, and in some others, it only can be detected through microscope. Blood in urine is clinically called hematuria in medicine and the severity of it reflects the severity of IgA Nephropathy. Tight control of blood in urine help to slow down illness progress; but how to reduce blood in urine associated with IgA Nephropathy?

What is IgA Nephropathy?

IgA Nephropathy is an autoimmune disease in which kidney is damaged by IgA deposition in kidney. IgA (Immunoglobulin A) is an antibody that plays a critical role in mucosal immunity. It helps to fight against harmful substances in normal condition, but in cases of IgA Nephropathy, due to immune disorder, large amounts of IgA are produced. These IgA can be normal or abnormal. They circulate with blood and finally lodge in mesangial area. This cause severe inflammatory response of our kidney. Inflammatory reaction helps to remove IgA from kidney, but meanwhile it causes damages on kidney. IgA Nephropathy is diagnosed when kidney tissues are injured due to inflammatory response resulted from IgA deposition in kidney.

How is IgA associated with blood in urine?

In early stage of IgA Nephropathy, no blood can be detected in urine, because inflammatory response is mild and kidney damages are also mild. However, with the deterioration of illness, glomeruli are finally damaged. Under such a condition, when blood pass through kidney, red blood cells are leaked into urine due to damaged glomeruli. Hematuria is diagnosed when red blood cell count in urine is higher than the reference value.

How to reduce blood in urine with IgA Nephropathy?

Blood in urine is just one of the symptoms of IgA Nephropathy and if we want to get this symptom removed permanently, we must treat IgA Nephropathy fundamentally. On the pathogenesis of IgA Nephropathy, right treatment for IgA Nephropathy should include:

1. Normalization of immune system: The purpose of this is to stop further formation of IgA.

2. Blocking of inflammation: Kidney is injured due to inflammation, so before IgA is removed, blocking for inflammation is very necessary.

3. Clearance of excess IgA in blood and kidney: This is done to stop further inflammatory response.

4. Repairing of kidney damages: Only when kidney damages are repaired, can kidney function be improved and also can leakage of red blood cell be stopped effectively.

5. Scientific diet to reduce kidney burden.

Lastly, in cases of IgA Nephropathy, blood in urine is just one of the clinical manifestations of kidney damage, so the treatment must start from treating IgA Nephropathy. Only when IgA Nephropathy get controlled and kidney function improved, can blood in urine be reduce successfully.