Causes Of IgA Nephropathy

IgA Nephropathy or Berger’s Disease is a glomerular disease caused by the deposition of immune complex. How do you understand this? Well, this article will tell you what causes IgA Nephropathy.

IgA, standing for immunoglobulin A, is a normal part of body’s immune system. When bacteria intrude your body, the organism produce various antibodies. Due to disorders of the immune system, IgA produced by your body will be abnormal and when they combine with antigen, IgA immune complexes will be formed. In that case, IgA immune complexes can not be excreted out of your body and they will deposit in the mesangial areas, leading to abnormal inflammations in the kidneys. As a result, surrounding renal intrinsic cells and tissues will be damaged. In this case, red blood cells leak into urine, forming blood urine which is clinically called hematuria.

Besides, you should also know genetics play an important role in the build up of IgA protein in the kidney. In more than 10 percent of affected families, the person suffers from IgA Nephropathy by an autosomal dominant gene. Autosomal dominant gene inheritance means that the gene is located on one of the autosomes. This means that the males and females have the equal chance to get IgA Nephropathy and dominant means that only one gene has the trait. When a parent has the dominant trait, his or her child will have 50 percent chance to inherit this trait.

IgA Nephropathy is very changing disease, which means the presentation varies greatly between individuals and families. In fact, some people inheriting the gene may have no symptoms, but the next generations may inherit the gene. And men are more likely to experience IgA Nephropathy than women.

In this article, I only give you a brief introduction of IgA Nephropathy causes and hope that they are beneficial to you. If you want to know more about the causes of IgA Nephropathy, you can leave us a message or consult our consultant online directly.