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What about the Prognosis for FSGS

2012-10-22 09:31

Focal Segmental glomerulosclerosis (FSGS) is a histologic finding that may result from a variety of insults to the kidneys. When diagnosed as this disease, people are quite concerned about the prognosis or how long they will live with FSGS. If people get this disease, timely and active treatment is essential to slow down progression of FSGS and improve prognosis.

FSGS is diagnosed based on the pathological presence detected from renal biopsy. It can be primary or secondary to another medical condition. FSGS is characterized by segmental lesion to on some of renal glomerular cells. Glomerular cells are responsible for stopping leakage of proteins from urine. FSGS typically presents with proteinuria. If not treated, most patients with FSGS will eventually develop complete renal failure and require dialysis or kidney transplant to live.

Up to now, many researches have been started on the factors that will affect the prognosis of FSGS. In long-term studies in adults and children with primary FSGS, renal survival has been directly associated with degrees of proteinuria controls, as is proven by some experimental researches. According Stephen M. Korbet, Dr from West Washington Boulevard, in Nephrotic syndrome patients who have massive proteinuria, progression to ESRD often occurs often the course of 5-10 years, whereas non-nephrotic syndrome patients and those entering a remission have an extremely favorable prognosis.

Specific forms of FSGS have been associated with different rates of progression and responsiveness to therapy. The appearance of your kidney biopsy under the microscope may give your doctor some idea of the time frame. Patients who are resistant to therapies have a significant likelihood of progressing to end-stage renal disease (ESRD).

Current medications for control of FSGS use a stepwise approach with a goal of normalization of urinary protein excretion and the prevention of kidney failure. Medical progression in this FSGS treatment field remains a priority in order to prevent the deterioration toward renal failure for patients proven to be resistant to treatment and to identify therapeutic regimens with minimal toxicity.


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