How Does IgA Nephropathy Lead to FSGS

Are you or your lover diagnosed with IgA deposits and FSGS? If so, you may be quite curious about the reason. How does IgA Nephropathy lead to FSGS? Today, follow me to find the answer.

IgA Nephropathy is one primary glomerular disease that is due to different factors. In most cases, IgA Nephropathy is characterized by the deposition of polymer IgA (PIgA) along with C3, IgG and IgM. It means abnormal IgA immune system leads to the presence of PIgA in circulatory system and its deposition in glomerular mesangial area. In addition, the onset of IgA Nephropathy may also have a link with bone marrow and inflammatory factors secreted by mesangial cells.

According to pathologic changes, IgA Nephropathy is divided into five classes. Generally, most glomeruli and renal tubules are not damaged in the early stage. However, as the condition progresses, the IgA deposition will cause more and more damage to glomeruli and renal tubules. During this process, FSGS occurs easily and symptoms as follows can help us detect FSGS early.

● High blood pressure

● Hematuria, especially microscopic hematuria

● Proteinuria

● Swelling around in eyes, hands and feet and it may be painful

● High cholesterol level

If you are diagnosed with IgA Nephropathy and have one or more symptoms the above mentioned, kidney experts here suggest you to do a kidney biopsy to see whether you also have FSGS. Making an accurate diagnosis is a must to guarantee you accept an effective treatment.

For people whose FSGS is due to IgA Nephropathy, steroid like cortisone and immunosuppressive agents like cyclosporin are commonly used to control their condition. However, if their FSGS and IgA Nephropathy are too serious to be treated by these medicines, blood purification or Immunotherapy will be recommended.

Summary

In clinic, IgA Nephropathy and FSGS coexist in some patients. Because different patients have different conditions, the detailed treatment should change from person to person. Therefore, you should consult doctor before taking any treatment. If you want to learn more about these two diseases or the above treatment options, you can leave a message or consult our online doctor, so we can help you solve your question in 24 hour.