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6 Symptoms of Diabetic Nephropathy

2012-09-26 17:31

In the early stage there is no obvious symptom and the blood pressure can be normal or slightly high. The radioimmunoassay can detect the microalbuminuria is more than 200mg/min and this stage is called early stage renal disease. If the high blood pressure and high blood sugar can be brought under control, it still has great chance to reverse the renal damages or the illness will progress into clinical diabetic nephropathy and it has the following clinical manifestations:

1. Proteinuria. At first there is only microalbuminuria in the urine and it is selective proteinuria with no increase of globulin and this condition can last for several years. With the enlarged filter hole of the glomerular basement membrane, macromolecular proteins can be found in urine and proteinuria will become worse and worse. Daily protein leakage in urine is an indicator of poor prognosis.

2. Edema. Early diabetic nephropathy patients usually have no edema and when protein urine is more than 3g/d there will be edema and obvious systemic edema can only occur to those that have rapid illness progression.

3. High blood pressure. It is common in diabetic nephropathy and high blood pressure will aggravate renal damages in diabetic nephropathy, therefore effective control of blood pressure is of great importance.

4. Renal insufficiency. It is a progressive process and will in the end develop azotemia and renal failure if left untreated.

5. Anemia. Those that have severe azotemia usually have anemia which can not be alleviated by iron agents. It is caused by the erythropoiesis and it might be related to the limitation of protein intake.

6. Retinopathy. It is not manifestation of renal damage but is often co-exist with diabetic nephropathy. This is because diabetes can damage the small blood vessels and this can lead to decline of vision or even blindness.


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