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Are There Genetic Factors Causing Diabetic Nephropathy

2014-10-02 01:47

Are There Genetic Factors Causing Diabetic NephropathyWhich genetic factors can lead to Diabetic Nephropathy (DN)? In DN susceptibility testing, many researches deem that genetic factors play an important role in the occurrence and development of diabetic nephropathy. Well, the following article will introduce what genetic factors can lead to DN.

1. Angiotensin converting enzyme (ACE)

Gene polymorphism of ACE is related to the occurrence of diabetic nephropathy. Aldose reductase, sorbitol dehydrogenase: increased aldose reductase activity in red blood cells is the susceptibility factor of diabetic nephropathy, while the reduced sorbitol dehydrogenase activity makes patients at a higher risk of kidney disease.

2. Primary high blood pressure

Diabetic Nephropathy patients’ blood pressure in parents with diabetes is obviously higher patients without diabetic nephropathy.

3. N-deacetylase

Decreased heparan sulfate proteoglycan (Hs-PG)can lead to protein in urine and progressively enlarged glomerular mesangial area.

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