Blood Purification To Remove High Creatinine In Blood

Creatinine is a waste product that is released into the blood after muscle contraction. Under normal circumstance, it is filtered out in the kidneys and be passed along with urine.

Kidney diseases can affect the discharging of creatinine and other wastes due to loss of kidney functions. When illness progressed into the end stage in which less than 15%-10% kidney functions are left, patients will have to rely on dialysis to remove excess creatinine and other wastes and toxins from the body.

Though dialysis is effective at removing too much creatinine from the blood, sometimes high creatinine can not be lowered after dialysis. There can be several reasons and one major cause is that the dialysis is inadequate.

Dialysis is one blood purification technology which can help remove excessive water, electrolytes, creatinine, blood urea nitrogen, uric acid from the blood. However dialysis can only remove small molecular substances, there are also many middle-sized or macromolecular wastes in the blood which can not be removed by dialysis.

More advanced blood purification technologies are now available to kidney disease patients. They include hemofiltration, hemoperfusion, plasma exchange, immune adsorption, etc. They can be applied alone or combined with dialysis to greatly improve the clearance rate and achieve better curative effects.

Hemofiltration is better than dialysis in case of the following conditions including heart failure, low blood pressure, water and sodium retention, acute kidney failure, hepatic coma, etc.

Hemoperfusion can effectively remove creatinine, uric acid, phenol, guanidine, indole, organic acids as well as the breakdown of many drugs. But it can not remove urea, phosphate, excessive water and electrolytes, it is often combined with hemodialysis in clinic.

Plasma exchange has particularly good effects at treating auto-immune kidney disease. It can help remove some soluble immune complexes.

Immune adsorption is based on plasma exchange and it is more advanced. It can selectively or specifically remove pathogenesis from the blood.

After blood is purified and the internal environment is cleared, immunotherapy is usually adopted to repair damaged renal tissues so as to gradually recover kidney functions. When kidney functions are improved, high creatinine will be reduced naturally.