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How to Improve the Prognosis of Amyloid Nephropathy

2012-10-13 09:17

It is known that the prognosis of amyloid nephropathy is poor at least compared with other glomerular diseases. The main causes of death are heart failure, arrhythmia, and sudden death, hear failure, etc.

Amyloid can be subdivided into two major categories according different causes---primary and secondary and they have different prognosis.

The average survival time for primary amyloid nephropathy (caused by amyloid-protein light chain derived) is about 12 months and those that are accompanied by heart failure or kidney failure have the poorest prognosis. The average survival time for secondary amyloid nephropathy (caused by amyloid-protein A) is about 45 months and there are about 35% die of kidney failure. If the amyloid nephropathy is caused by myeloma, the average survival time is about 5 months. This is just the general condition and the prognosis of the disease has much to do with the primary disease and the involved degree of vital organs. Anyway, an early diagnosis is of significance for improving the prognosis.

At present, there is no effective cure for amyloid nephropathy. The western therapies mainly adopt hormones and immunosuppressant which have been proved not effective and can not reverse the renal damages. If steroid therapy can be combined with Traditional Chinese Medicines the effects can be better.

Renal damages in amyloid nephropathy are caused by deposition of amyloid in the kidneys and in the early stage the main clinical manifestations are proteinuria and nephrotic syndrome and in the end stage will lead to renal failure. Therefore to improve the prognosis is to slow down its progression into renal failure. The proteinuria is caused by impairments of renal intrinsic cells and increased permeability of the glomerular filtration membrane. Therefore the first step is to deal with proteinuria. Western hormones are effective at alleviating protein in urine and Chinese herbal medicines can help repair damaged renal tissues, therefore a timely an proper combination of Chinese and western therapies can slow down the progression and greatly improve the prognosis.


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