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Is Renal Amyloidosis Hereditary

2012-10-15 15:42

Renal Amyloidosis is a kind of kidney disorder characterized by deposition of heavy amyloid substances on the kidneys. The damage of amyloidosis is actually not limited in the kidneys, but also can involve in brain, heart, joints, lungs, etc. The prognosis of amylodosis is greatly by the involved complications and severity of accompanying conditions. Is Renal Amylodosis Hereditary? Actually, it is not renal amyloidosis, the secondary complication is genetic, but some (not all) cases of amyloidosis are associated with genetic conditions or family histories.

What is Amylodosis? Amyloid is an abnormal protein usually produced by cells in bone morrow that can be deposited in any tissue or organ. Amyloidosis is a disease that occurs when the amyloid proteins build up in your organs. Amyloidosis can affect different organs in different people, and frequently affected organs include heart, kidneys, liver, spleen, nervous system and gastrointestinal tract. The disease is complicated just because the people often have problems in no more than one vital organ. For people with renal Amyloidosis, the severity of kidney damage and extent of other organ damage will have a direct effect on the prognosis in the patients.

Who can develop amlyloidosis? Is Amyloidosis hereditary? Anyone can develop Amyloidosis, but certain factors place you at greater risks. First is being older than 60 years. In addition, you will at an increased risk if you have a chronic or inflammatory disease. People who have multiple myeloma----a form of bone morrow cancer—are also at higher risks.

In some cases, amyloidosis is hereditary. The mode of transmission in hereditary amyloidosis is Autosomal dominant, which means that if a father or mother has this type of amyloidosis, each of their children has a 50% chance of inheriting the same mutation and having the same disease. If the disease does not inherit the genes then they can not pass it on to future generation. Some other cases of amyloidosis have been illustrated to be associated to long-term of dialysis. The people develop renal amyloidosis as a result of the dialysis, on the contrary, developing the condition will worsen the illness condition in the people.

As we can conclude, having a family history means a greatly increased chance of renal amylodosis; while other conditions can also give rise to the disease. If you experience the symptoms of renal amyloidosis, see the doctor so that the underlying cause of the disease can be determined.

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